Influence of the body mass and visceral adiposity on glucose metabolism in obese women with Pro12Pro genotype in PPARgamma2 gene.

Introduction: Glucose metabolism may be altered in obesity and genotype for PPAR 2 can influence this variable. Objective: To evaluate the influence of body mass (BM) and visceral adiposity (VA) in glucose metabolism in morbid obese women with Pro12Pro genotype. Methods: Were selected 25 morbidly obese women. Groups were formed according to body mass index (BMI) [G1: 40-45 kg/m2 (n = 17); G2: > 45 kg/m2 (n = 8)]. Anthropometric, glycemia and insulinemia assessments (fasting, 60 and 120 minutes after high polyunsaturated fatty acids meal) were carried out. The insulin resistance (IR) and insulin sensitivity (IS) were assessed by HOMA-IR and QUICKI respectively. Results: G2 had higher BMI and waist circumference, compared to G1, impaired fasting glucose, low IS and higher IR. The postprandial glucose was normal, but there was a higher insulin peak one hour after the meal in G2. Conclusion: Increased BM and VA were associated with worse glucose metabolism suggesting metabolic differences between morbid obese with Pro12Pro genotype.

Bibliographic Details

Main Authors:	KAIPPERT, V. C., UEHARA, S. K., D'ANDREA, C. L., NOGUEIRA, J., LAGO, M. F. do, LOPES, M. C. O. dos S., OLIVEIRA, E. M. M., ROSADO, E. L.
Other Authors:	VANESSA CHAIA KAIPPERT, UFRJ; SOFIA KIMI UEHARA, UFRJ; CARLA LIMA D'ANDREA, UFRJ; JULIANA NOGUEIRA, UFRJ; MÁRCIA FÓFANO DO LAGO, UFRJ; MARCELLY CUNHA OLIVEIRA DOS SANTOS, UFRJ; EDNA MARIA MORAIS OLIVEIRA, CTAA; ELIANE LOPES ROSADO, UFRJ.
Format:	Separatas biblioteca
Language:	English eng
Published:	2013-06-27
Subjects:	Índice de massa corporal, Resistência à insulina, Metabolismo da glicose, PPARgamma., Obesidade.,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/960737
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