Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin

Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin

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Background: Many seaweed polysaccharides have anticoagulant activity, but the mechanism of action was elucidated in a few cases. Results: A highly sulfated pyranosic ß-arabinan exerts its activity through direct and indirect inhibition of thrombin. Conclusion: The structure and mechanism of action of the arabinan are different from those found for other polysaccharides. Significance: This arabinan could be an alternative anticoagulant in certain specific cases.

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Bibliographic Details
Main Authors: Fernández, Paula Virginia, Quintana, Irene, Cerezo, Alberto S., Caramelo, Julio J., Pol Fachin, Laercio, Verli, Hugo, Estévez, José Manuel, Ciancia, Marina
Format: Texto biblioteca
Language:eng
Subjects:ANTICOAGULANT ACTIVITIES, AMINO ACID RESIDUES, ARABINANS, SULFATED POLYSACCHARIDES,
Online Access:http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber=47865
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id KOHA-OAI-AGRO:47865
record_format koha
spelling KOHA-OAI-AGRO:478652023-08-17T13:59:09Zhttp://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber=47865http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber=http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber=http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber=AAGAnticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with ThrombinFernández, Paula VirginiaQuintana, IreneCerezo, Alberto S.Caramelo, Julio J.Pol Fachin, LaercioVerli, HugoEstévez, José ManuelCiancia, Marinatextengapplication/pdfBackground: Many seaweed polysaccharides have anticoagulant activity, but the mechanism of action was elucidated in a few cases. Results: A highly sulfated pyranosic ß-arabinan exerts its activity through direct and indirect inhibition of thrombin. Conclusion: The structure and mechanism of action of the arabinan are different from those found for other polysaccharides. Significance: This arabinan could be an alternative anticoagulant in certain specific cases.Background: Many seaweed polysaccharides have anticoagulant activity, but the mechanism of action was elucidated in a few cases. Results: A highly sulfated pyranosic ß-arabinan exerts its activity through direct and indirect inhibition of thrombin. Conclusion: The structure and mechanism of action of the arabinan are different from those found for other polysaccharides. Significance: This arabinan could be an alternative anticoagulant in certain specific cases.ANTICOAGULANT ACTIVITIESAMINO ACID RESIDUESARABINANSSULFATED POLYSACCHARIDESThe journal of biological chemistry
institution UBA FA
collection Koha
country Argentina
countrycode AR
component Bibliográfico
access En linea
En linea
databasecode cat-ceiba
tag biblioteca
region America del Sur
libraryname Biblioteca Central FAUBA
language eng
topic ANTICOAGULANT ACTIVITIES
AMINO ACID RESIDUES
ARABINANS
SULFATED POLYSACCHARIDES
ANTICOAGULANT ACTIVITIES
AMINO ACID RESIDUES
ARABINANS
SULFATED POLYSACCHARIDES
spellingShingle ANTICOAGULANT ACTIVITIES
AMINO ACID RESIDUES
ARABINANS
SULFATED POLYSACCHARIDES
ANTICOAGULANT ACTIVITIES
AMINO ACID RESIDUES
ARABINANS
SULFATED POLYSACCHARIDES
Fernández, Paula Virginia
Quintana, Irene
Cerezo, Alberto S.
Caramelo, Julio J.
Pol Fachin, Laercio
Verli, Hugo
Estévez, José Manuel
Ciancia, Marina
Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin
description Background: Many seaweed polysaccharides have anticoagulant activity, but the mechanism of action was elucidated in a few cases. Results: A highly sulfated pyranosic ß-arabinan exerts its activity through direct and indirect inhibition of thrombin. Conclusion: The structure and mechanism of action of the arabinan are different from those found for other polysaccharides. Significance: This arabinan could be an alternative anticoagulant in certain specific cases.
format Texto
topic_facet ANTICOAGULANT ACTIVITIES
AMINO ACID RESIDUES
ARABINANS
SULFATED POLYSACCHARIDES
author Fernández, Paula Virginia
Quintana, Irene
Cerezo, Alberto S.
Caramelo, Julio J.
Pol Fachin, Laercio
Verli, Hugo
Estévez, José Manuel
Ciancia, Marina
author_facet Fernández, Paula Virginia
Quintana, Irene
Cerezo, Alberto S.
Caramelo, Julio J.
Pol Fachin, Laercio
Verli, Hugo
Estévez, José Manuel
Ciancia, Marina
author_sort Fernández, Paula Virginia
title Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin
title_short Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin
title_full Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin
title_fullStr Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin
title_full_unstemmed Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin
title_sort anticoagulant activity of a unique sulfated pyranosic (133) - ß - l - arabinan through direct interaction with thrombin
url http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber=47865
http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber=
http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber=
http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber=
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AT quintanairene anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
AT cerezoalbertos anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
AT caramelojulioj anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
AT polfachinlaercio anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
AT verlihugo anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
AT estevezjosemanuel anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
AT cianciamarina anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
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