Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin
Background: Many seaweed polysaccharides have anticoagulant activity, but the mechanism of action was elucidated in a few cases. Results: A highly sulfated pyranosic ß-arabinan exerts its activity through direct and indirect inhibition of thrombin. Conclusion: The structure and mechanism of action of the arabinan are different from those found for other polysaccharides. Significance: This arabinan could be an alternative anticoagulant in certain specific cases.
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| Main Authors: | , , , , , , , |
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| Format: | Texto biblioteca |
| Language: | eng |
| Subjects: | ANTICOAGULANT ACTIVITIES, AMINO ACID RESIDUES, ARABINANS, SULFATED POLYSACCHARIDES, |
| Online Access: | http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber=47865 http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber= http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber= http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber= |
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| Summary: | Background: Many seaweed polysaccharides have anticoagulant activity, but the mechanism of action was elucidated in a few cases.
Results: A highly sulfated pyranosic ß-arabinan exerts its activity through direct and indirect inhibition of thrombin.
Conclusion: The structure and mechanism of action of the arabinan are different from those found for other polysaccharides.
Significance: This arabinan could be an alternative anticoagulant in certain specific cases. |
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