Evaluation of two adjuvants for the formulation of antitetanic vaccines
The objective of this research was to compare the role of two adjuvants, aluminum hydroxide and calcium phosphate, with two different tetanus toxoid batches, one obtained by stationary culture and the other one by sumerged culture. The generated immune response was evaluated through the potency assay of the National Institute of Health (NIH), which states that in order to guaranty that the vaccines are within the established standards the immune response has to be at least 2UI/mL. The results indicate that aluminum hydroxide presents in most cases better titers, while in other cases no significant difference was found. Results showed also, that both adjuvants gave a better immune response with batch 69 (static culture) than with batch 11 (sumerged culture). The variance analysis showed an error of p< 0.002.
| Main Authors: | , , , , |
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| Format: | Digital revista |
| Language: | spa |
| Published: |
Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
2007
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| Online Access: | https://revistas.udca.edu.co/index.php/ruadc/article/view/575 |
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