TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice

Abstract: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously that TRPC3 channels are effectors of the brain-derived neurotrophic factor (BDNF)/trkB signaling pathway. Given the long postulated role of BDNF in epileptogenesis, TRPC3 channels may be a critical component in the underlying pathophysiology of seizure and epilepsy. In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE).

Bibliographic Details

Main Authors:	Phelan, Kevin D., Shwe, U Thaung, Cozart, Michael A., Wu, Hong, Mock, Matthew M., Abramowitz, Joel, Birnbaumer, Lutz, Zheng, Fang
Format:	Artículo biblioteca
Language:	eng
Published:	Wiley 2017
Subjects:	ELECTROENCEFALOGRAFIA, NEURONAS, ANALISIS ESPECTRAL, SISTEMA NERVIOSO, MEDICAMENTOS, EPILEPSIA,
Online Access:	https://repositorio.uca.edu.ar/handle/123456789/8738
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