TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
Abstract: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously that TRPC3 channels are effectors of the brain-derived neurotrophic factor (BDNF)/trkB signaling pathway. Given the long postulated role of BDNF in epileptogenesis, TRPC3 channels may be a critical component in the underlying pathophysiology of seizure and epilepsy. In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE).
Main Authors: | , , , , , , , |
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Format: | Artículo biblioteca |
Language: | eng |
Published: |
Wiley
2017
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Subjects: | ELECTROENCEFALOGRAFIA, NEURONAS, ANALISIS ESPECTRAL, SISTEMA NERVIOSO, MEDICAMENTOS, EPILEPSIA, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/8738 |
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