Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
Abstract: To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly under both treatments whereas excessive body weight was seen in rats receiving the 10% fructose only. Rats drinking 5% fructose showed a greater tolerance to a glucose load while rats having access to a 10% fructose drinking solution exhibited the expected impaired glucose tolerance found in the metabolic syndrome. Circulating triglyceride and low density lipoproteins-cholesterol (LDL-c) concentration augmented significantly in rats showing a fully developed metabolic syndrome only, while high blood cholesterol levels were found at both stages examined. Melatonin (25 μg/mL drinking solution) counteracted the changes in body weight and systolic blood pressure found in rats administered with fructose. Melatonin decreased the abnormal hyperglycemia seen after a glucose load in 10% fructose-treated rats but it did not modify the greater tolerance to glucose observed in animals drinking 5% fructose. Melatonin also counteracted the changes in plasma LDL-c, triglyceride and cholesterol levels and decreased plasma uric acid levels. The results underline a possible therapeutical role of melatonin in the metabolic syndrome, both at initial and established phases
| Main Authors: | , , , , |
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| Format: | Artículo biblioteca |
| Language: | eng eng |
| Published: |
Multidisciplinary Digital Publishing Institute
2013
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| Subjects: | SINDROME METABOLICO, MELATONINA, HIPERTENSION, FRUCTOSA, DISLIPIDEMIA, OBESIDAD, TOLERANCIA A LA GLUCOSA, |
| Online Access: | https://repositorio.uca.edu.ar/handle/123456789/1639 |
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