Stevens-Johnson syndrome/toxic epidermal necrolysis overlap triggered by ethosuximide: a rare pediatric report

Abstract Introduction: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe and life-threatening mucocutaneous conditions characterized by fever and necrosis of the epidermis. Up to 90% of cases are drug-induced. Antiseizure drugs (ASD) are known to cause SJS, but only a very few ethosuximide-induced SJS cases have been reported in the literature. Case presentation: We report a case of ethosuximide-induced SJS/TEN overlap in a 4-year-old boy, confirmed by patch tests, with improvement with intravenous immunoglobulin (IVIG) and systemic corticosteroid therapy cycle. Conclusion: This case highlights the need to expand knowledge about the optimal treatment strategy for these rare conditions, in addition to supportive treatment.

Bibliographic Details

Main Authors:	Soares-Cardoso,Sandra, Pimenta,Joana, Belinha,Flávia, Salgado,Manuel, Rato,Margarida, Pereira,Cristina, Ramos,Leonor
Format:	Digital revista
Language:	English
Published:	Permanyer Publications 2023
Online Access:	http://scielo.pt/scielo.php?script=sci_arttext&pid=S2795-50012023000200124
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