Phytochemical screening and biological assays of ethanolic leaf extract of Senna rugosa

Abstract Senna rugosa (Fabaceae) is a common specie of the Brazilian territory, especially in the Cerrado biome. It is widely used in the popular medicine although not yet adequately investigated as to its phytoconstituents and pharmacological activities. In this study, the preliminary phytochemical analysis of ethanolic leaf extract of S. rugosa was performed and its cytotoxicity, antitumoral and antimicrobial activities (antibacterial, antifungal, anti-Trypanosoma and anti-Leishmania) were evaluated. The crude extract was analyzed in HPLC-DAD and fractions were also characterized using GC-MS and ESI-MS techniques. Results indicate phenolic compounds majority presence, including flavonol, anthraquinone and anthrones derivatives. Relative antimicrobial activities were detected against Staphylococcus aureus, Pseudomonas aeruginosa, Candida famata, Candida krusei and Candida tropicalis. As well as, a weak anti-trypanosomatids activity against M2269 strain and BH46 strain of Leishmania sp. A relative antitumoral activity was also identified but in counterpoint were also observed a toxicity in fibroblast cells (L929). Phytochemically, results provide evidence that phenolic compounds in S. rugosa leaves might be the responsible for its antimicrobial activity and cell toxicity inferred in our research.

Bibliographic Details

Main Authors:	Cunha,Letícia Figueiredo, Costa,Camila Marques, Barroso,Poliana Ribeiro, Kato,Kelly Cristina, Oliveira,Fabrício de, Mendonça Filho,Carlos Victor, Grael,Cristiane Fernanda Fuzer, Gregório,Luiz Elídio, Campos,Fernanda Fraga, Oliveira,Patrícia Machado de, Oliveira,Danilo Bretas de, Ruela,Fernando Armini, Martins,Helen Rodrigues
Format:	Digital revista
Language:	English
Published:	Instituto de Pesquisas Jardim Botânico do Rio de Janeiro 2020
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2175-78602020000100709
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