In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes

ABSTRACT Griseofulvin (GF) and terbinafine (TF) are commonly used drugs to treat dermatophytosis, a fungal infection of the skin. Today there is an increase in drug resistance to these antifungals which highlight the need for alternative synergistic therapies. Minimum Inhibitory Concentration (MIC) of GF and TF were determined against fungi clinical isolates from local hospitals with values ranging 0.03-2.0 µg mL-1 and 0.24-4.0 µg mL-1, respectively. A checkboard test was used to determine the combination of GF:TF which could induce an additive effect against the fungi isolates Multidrug-resistant isolates showed susceptibility after treatment with 16:2 µg mL-1 GF:TF. An MTT assay further verified that GF and TF combinations have greater additive effect against pathological and multidrug-resistant isolates than antifungals alone. Herein we disclose GF:TF combinations that could constitute as a possible new anti-dermatophyte therapy.

Bibliographic Details

Main Authors:	Lana,Aline Jacobi Dalla, Pippi,Bruna, Carvalho,Anderson Ramos, Moraes,Renata Cougo, Kaiser,Samuel, Ortega,George Gonzalez, Fuentefria,Alexandre Meneghello, Silveira,Gustavo Pozza
Format:	Digital revista
Language:	English
Published:	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 2018
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200623
Tags:	Add Tag No Tags, Be the first to tag this record!