Evaluation of polymeric PLGA nanoparticles conjugated to curcumin for use in aPDT

ABSTRACT Antimicrobial photodynamic therapy (aPDT) involves the association of a photosensitizing agent with a light source with the goal of causing apoptosis or microbial lysing. The use of compounds with natural active principles is gaining prominence throughout the world. Several studies from groups that are linked to the development of innovations in the pharmaceutical market have used natural dyes, such as curcumin, the efficacy of which has been demonstrated in aPDT trials. Difficulties related to physicochemical stability, solubility and cell penetration are some of the challenges associated with this field. The present work aimed to prepare, investigate the characteristics and improve the photodynamic activity of PLGA-based nanoparticles loaded with curcumin for use in aPDT therapy. Using the simple technique of emulsion during the evaporation of a solvent, the particles were built, characterized and tested against microorganisms with importance for medicine and dentistry. The results revealed that the particles were able to protect the curcumin against degradation and eliminate some microorganism species at nanomolar concentrations.

Bibliographic Details

Main Authors:	Pietra,Renata Celi Carvalho de Souza, Cruz,Rosana Carvalho, Melo,Carla Nunes, Rodrigues,Lívia Bomfim, Santos,Patrícia Campi, Bretz,Gabriel Pissolati Matos, Soares,Betânia Maria, Sousa,Gerdal Roberto de, Ferreira,Marcus Vinícius Lucas, Cisalpino,Patrícia Silva, Magalhães,Paula Prazeres, Farias,Luiz de Macêdo, Pinotti,Marcos
Format:	Digital revista
Language:	English
Published:	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 2017
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200629
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