Wound-healing evaluation of ointment from Stryphnodendron adstringens (barbatimão) in rat skin

This study evaluated the cicatrizant effect of an ointment containing 1% of the ethyl-acetate fraction extracted from the stem bark of "barbatimão" (Stryphnodendron adstringens), in wounds made in the skin of rats, after 4, 7 and 10 days of treatment. Control wounds were treated with a base ointment without extract. The proliferation of keratinocytes in the area of reepithelialization was evaluated by counting the number of epithelial cells that were blocked in metaphase by vincristine sulfate. The length of the reepithelialized margin and the contraction of the wound were measured. Topical application of the "barbatimão" ointment stimulated proliferation of the keratinocytes, but had no effect on the length of the epithelium or on the contraction of the wounds.

Bibliographic Details

Main Authors:	Hernandes,Luzmarina, Pereira,Luciene Marques da Silva, Palazzo,Fabiana, Mello,João Carlos Palazzo de
Format:	Digital revista
Language:	English
Published:	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 2010
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300005
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