Kinetics and avidity of anti-Toxocara antibodies (IgG) in rabbits experimentally infected with Toxocara canis

Abstract An evaluation was made of the kinetics and avidity of anti-Toxocara antibodies (IgG) in rabbits experimentally infected with embryonated Toxocara canis eggs. Seventeen four month old New Zealand White rabbits were distributed into two groups. In the experimental group, twelve rabbits were infected orally with 1,000 embryonated T. canis eggs. A second group (n = 5), uninfected, was used as a control. Serum samples were collected for analysis on days 7, 14, 21, 28 and 60 post-infection (DPI). An indirect ELISA test was performed to evaluate the reactivity index (RI) of IgG anti-T. canis antibodies and to calculate the avidity index (AI). The animals showed seroconversion from the 14th DPI, with high AI (over 50%) except for one animal, which presented an intermediate AI. At 60 DPI, all the animals were seropositive and maintained a high AI. The data indicated that specific IgG antibodies formed early (14 DPI) in rabbits infected with T. canis, with a high avidity index that persisted throughout the course of the infection.

Bibliographic Details

Main Authors:	Bin,Lundia Luara Cavalcante, Santarém,Vamilton Alvares, Laposy,Cecília Braga, Rubinsky-Elefant,Guita, Roldán,William Henry, Giuffrida,Rogério
Format:	Digital revista
Language:	English
Published:	Colégio Brasileiro de Parasitologia Veterinária 2016
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612016000100099
Tags:	Add Tag No Tags, Be the first to tag this record!