Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs

Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7). Blood samples were collected on days 0, 10, 20 and 30 after infection, using tubes without anticoagulant to obtain serum and analyze the biochemical parameters. An increase in alanine aminotransferase (ALT) on day 20 (P < 0.05) was observed. Also, increased creatine kinase (CK) and aspartate aminotransferase (AST) levels were observed throughout the experimental period (P < 0.05). No changes in the serum gamma-glutamyltransferase, urea and creatinine levels were observed. Thus, is possible to conclude that experimental infection with R. vitalii in dogs causes changes to the biochemical profile, with increased ALT, AST and CK enzyme levels.

Bibliographic Details

Main Authors:	Costa,Márcio Machado, França,Raqueli Teresinha, Da Silva,Aleksandro Schafer, Paim,Carlos Breno, Paim,Francine, Amaral,Carlos Henrique do, Dornelles,Guilherme Lopes, Cunha,João Paulo Monteiro Carvalho Mori da, Soares,João Fabio, Labruna,Marcelo Bahia, Mazzanti,Cinthia Melazzo Andrade, Monteiro,Silvia Gonzalez, Lopes,Sonia Terezinha dos Anjos
Format:	Digital revista
Language:	English
Published:	Colégio Brasileiro de Parasitologia Veterinária 2012
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300012
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