Adverse drug reactions related to potential serious drug interactions in patients with cardiovascular diseases
ABSTRACT Objective: To assess the occurrence of adverse drug reactions associated with potential serious drug interactions identified in prescriptions of hospitalized patients with cardiovascular disease. Method: A documentary, quantitative, and cross-sectional research study. Between August and September 2016, ninety-nine prescriptions of patients hospitalized for more than 48 hours in the cardiology ward of a hospital in Rio de Janeiro were analyzed. Drug interactions were evaluated by Micromedex®, and adverse events were identified through trackers and analyzed by specialists using the Naranjo Algorithm, by means of descriptive statistics. Results: Eighteen potential serious interactions were detected in 22 drug pairs, mainly simvastatin x anlodipine (18%) and enoxaparin x clopidogrel (18%). Of the 18 medical records investigated, four trackers were found and three probable adverse events (16.6%) were defined due to hemorrhagic changes in patients. Conclusion: Drug interactions are likely to cause harm to the patient, which requires implementing barriers for the safety of the medication system.
| Main Authors: | , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Universidade Federal do Rio Grande do Sul. Escola de Enfermagem
2020
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-14472020000100452 |
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