Translation, cross-cultural adaptation and applicability of the Brazilian version of the Frontotemporal Dementia Rating Scale (FTD-FRS)

ABSTRACT Background: Staging scales for dementia have been devised for grading Alzheimer's disease (AD) but do not include the specific symptoms of frontotemporal lobar degeneration (FTLD). Objective: To translate and adapt the Frontotemporal Dementia Rating Scale (FTD-FRS) to Brazilian Portuguese. Methods: The cross-cultural adaptation process consisted of the following steps: translation, back-translation (prepared by independent translators), discussion with specialists, and development of a final version after minor adjustments. A pilot application was carried out with 12 patients diagnosed with bvFTD and 11 with AD, matched for disease severity (CDR=1.0). The evaluation protocol included: Addenbrooke's Cognitive Examination-Revised (ACE-R), Mini-Mental State Examination (MMSE), Executive Interview (EXIT-25), Neuropsychiatric Inventory (NPI), Frontotemporal Dementia Rating Scale (FTD-FRS) and Clinical Dementia Rating scale (CDR). Results: The Brazilian version of the FTD-FRS seemed appropriate for use in this country. Preliminary results revealed greater levels of disability in bvFTD than in AD patients (bvFTD: 25% mild, 50% moderate and 25% severe; AD: 36.36% mild, 63.64% moderate). It appears that the CDR underrates disease severity in bvFTD since a relevant proportion of patients rated as having mild dementia (CDR=1.0) in fact had moderate or severe levels of disability according to the FTD-FRS. Conclusion: The Brazilian version of the FTD-FRS seems suitable to aid staging and determining disease progression.

Bibliographic Details

Main Authors:	Lima-Silva,Thais Bento, Bahia,Valéria Santoro, Carvalho,Viviane Amaral, Guimarães,Henrique Cerqueira, Caramelli,Paulo, Balthazar,Márcio, Damasceno,Benito, Bottino,Cássio Machado de Campos, Brucki,Sônia Maria Dozzi, Mioshi,Eneida, Nitrini,Ricardo, Yassuda,Mônica Sanches
Format:	Digital revista
Language:	English
Published:	Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento 2013
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000400387
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