Subcortical ischemic vascular disease and cognition: A systematic review

Abstract Subcortical Ischemic Vascular Disease (SIVD) is underdiagnosed. This review investigates the relationship among SIVD severity, cognitive status and neuroimaging markers. Methods: Cohort, cross-sectional and case control studies were searched on ISI, Medline, Scielo, PsychoInfo and LILACS databases published between 1995 and 2006. Results: The most impaired cognitive domains were executive, attentional and memory retrieval mechanisms. These cognitive features were frequently associated to White Matter Lesions (WML). Conclusions: WML is an independent factor in cognitive decline. However, the threshold for this impact is not yet clearly established.

Bibliographic Details

Main Authors:	Alves,Gilberto Sousa, Alves,Carlos Eduardo de Oliveira, Lanna,Maria Elisa, Moreira,Denise Madeira, Engelhardt,Eliasz, Laks,Jerson
Format:	Digital revista
Language:	English
Published:	Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento 2008
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642008000200082
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