Diastereoselective Alkylation of Chiral Glycinate Derivatives Containing the α-Phenylethyl Group
Novel chiral glycinate derivatives (S)-6 and (S)-7 containing the α-phenylethyl group, were prepared and studied as potential precursors of enantiopure α-substituted-α-amino acids. In particular, the alkylation of enolate (S)-7-Li showed substantial (78:22 dr) stereoinduction by the N-(l-phenylethyl)benzamide chiral auxiliary. Addition of DMPU showed no appreciable effect upon the diastereoselectivity.
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| Main Authors: | , , , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Química de México A.C.
2011
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| Online Access: | http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2011000300004 |
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