Synthesis and Absolute Configuration of (20R)-20-Acetyl-23,24-bisnorcholanic Lactones Prepared from (E)-(20S,25R)- and (E)-(20S,25S)-20,23-Diacetylfurost-22-enes

Synthesis and Absolute Configuration of (20R)-20-Acetyl-23,24-bisnorcholanic Lactones Prepared from (E)-(20S,25R)- and (E)-(20S,25S)-20,23-Diacetylfurost-22-enes

The synthesis of (20R)-20-acetyl-23,24-bisnorcholanic lactones from (E)-(20S,25R)- and (E)-(20S,25R)-20,23-diacetylfurost-22-enes (derived from diosgenin, hecogenin and sarsasapogenin) is reported. The configuration of the stereogenic center at C-20 was determined by NMR and single crystal X-ray diffraction studies. The lactones can be used in the synthesis of a variety of steroidal derivatives.

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Bibliographic Details
Main Authors: Hernández Linares,Guadalupe, Meza Reyes,Socorro, Montiel Smith,Sara, Sandoval Ramírez,Jesús, Gómez Calvario,Víctor, Bernès,Sylvain
Format: Digital revista
Language:English
Published: Sociedad Química de México A.C. 2007
Online Access:http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2007000400009
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