Synthesis of Tramadol and Analogous
Tramadol is a drug with analgesic properties. This compound and five of its analogous were synthesized: N-demethyl (M2), O-demethyl (M1), O-ethyl-O-demethyl, O-benzyl-O-demethyl and N-benzyl-N-demethyl. All compounds were prepared as their hydrochlorides and as racemic mixtures. The synthesis started with the aminoketones; 2-(N-benzyl, N-methyl)aminomethyl cyclohexa-none and 2-dimethylaminomethyl cyclohexanone, prepared by means of a Mannich reaction of cyclohexanone, paraformaldehyde and the corresponding amino hydrochloride. The aminoketones were coupled with the organolithium compounds derived from the corresponding 3-bromoalkoxybenzenes.
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| Main Authors: | , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Química de México A.C.
2005
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| Online Access: | http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2005000400004 |
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