Synthesis of 2,4-Disubstituted Thiazole Combinatorial Unit on Solid-Phase: Microwave Assisted Conversion of Alcohol to Amine Monitored by FT-IR

Synthesis of 2,4-Disubstituted Thiazole Combinatorial Unit on Solid-Phase: Microwave Assisted Conversion of Alcohol to Amine Monitored by FT-IR

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Microwave-assisted solid-phase synthesis of the 2,4-disubstituted thiazole 3 on Merrifield Resin is described. The hydroxyl moiety was converted to amine in five steps - including coupling and cleavage - within a total reaction time of 2 hours and 26% overall yield. The entire solid-phase synthesis was efficiently monitored by FT-IR/KBr pellets and allows potential use in combinatorial chemistry.

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Bibliographic Details
Main Authors: Antonow,Dyeison, Mahler,S. Graciela, Serra,Gloria L., Manta,Eduardo, Eifler-Lima,Vera Lucia
Format: Digital revista
Language:English
Published: Sociedad Química de México A.C. 2005
Online Access:http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2005000200022
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http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2005000200022

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