Co-treatment of wounds in rabbit skin with equine platelet-rich plasma and a commercial ointment accelerates healing

Abstract Autologous platelet-rich plasma (PRP) is beneficial in the healing process of reconstructive surgeries, contributing to the stimulation of angiogenesis; however, heterologous plasma has been shown to be more effective. The objective of this study was to verify, by macro- and microscopic evaluation, whether PRP accelerates the healing process as compared to a commercial ointment containing gentamicin, sulfanilamide, sulfadiazine, urea, and vitamin A (study ointment). This study used 24 white New Zealand rabbits, aged 12 months, and each weighing approximately 3 kg. The animals were separated into 4 equal groups and underwent wound induction through skin removal in the thoracic (study wound) and lumbar (control wound) dorsal midline. Study wounds were co-treated with equine PRP and the study ointment. Control wounds were treated with only the study ointment. Group I underwent histological evaluation 3 days after the skin removal procedure, group II after 7 days, group III after 14 days, and group IV after 21 days. A skin fragment was collected from each animal for histological evaluation. The co-treatment with heterologous equine PRP and the study ointment accelerated the healing process in the surgically induced skin wounds, confirming the acceleratory effect of PRP on wound healing.

Bibliographic Details

Main Authors:	Rezende,Rodrigo Supranzetti de, Eurides,Duvaldo, Alves,Endrigo Gabelline Leonel, Venturini,Guilherme Costa, Felipe,Rodrigo Lopes de
Format:	Digital revista
Language:	English
Published:	Universidade Federal de Goiás 2020
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-68912020000100308
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