Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults

OBJECTIVES: The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events. METHODS: Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA). RESULTS: Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p<0.001), and these associations were independent of the context. CONCLUSION: Our results suggest that serum Klotho is higher in individuals with a clinical history of myocardial infarction but not with a history of coronary artery disease or stroke. None of the Klotho haplotypes were associated with the variables investigated herein.

Bibliographic Details

Main Authors:	Paula,Roberta S., Souza,Vinícius C., Machado-Silva,Wilcelly, Almeida,Bruno Ratier S., Daros,Andersen C., Gomes,Lucy, Ferreira,Aparecido P., Brito,Ciro J., Córdova,Cláudio, Moraes,Clayton F., Nóbrega,Otávio T.
Format:	Digital revista
Language:	English
Published:	Faculdade de Medicina / USP 2016
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322016001200725
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