Drug hypersensitivity in students from São Paulo, Brazil

BACKGROUND: Drug hypersensitivity is responsible for substantial mortality and morbidity, and increased health costs. However, epidemiological data on drug hypersensitivity in general or specific populations are scarce. METHODS: We performed a cross-sectional survey of 1015 university students, using a self-reported questionnaire. RESULTS: The prevalence of self-reported drug hypersensitivity was 12,11% (123/1015). The most frequently implicated drugs were non-steroidal anti-inflammatory drugs (45,9%) and beta-lactam and sulfonamide antibiotics (25,40%). The majority of the patients reported dermatological manifestations (99), followed by respiratory (40), digestive (23) and other (19). Forty-five patients had an immediate type reaction, and 76,72% (89) had the drug by oral route. CONCLUSION: The results showed that drug hypersensitivity is highly prevalent in university students, and that nonsteroidal anti-inflammatory drug and antibiotics (beta-lactams and sulfonamide) are the most frequently concerned drugs.

Bibliographic Details

Main Authors:	Ensina,Luis Felipe Chiaverini, Amigo,Maria Helena Lopes, Koch,Thais, Guzman,Evelyn, Paoli,Renata, Nunes,Inês Cristina Camelo
Format:	Digital revista
Language:	English
Published:	Faculdade de Medicina / USP 2010
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010001000014
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