Percutaneous prostate cryoablation as treatment for high-risk prostate cancer

PURPOSE: To evaluate percutaneous cryotherapy as a primary treatment option for high-risk prostate cancer patients. PATIENTS AND METHODS: From October 2000 to February 2005, 21 high-risk (Gleason e•8 and/or PSA > 10 and/or stage > T2a) prostate cancer patients underwent 24 percutaneous prostate cryoablation procedures. Patients' median age was 70.9, and the average pretreatment PSA was 19.5 ng/dL. The follow-up period ranged from 6 to 60 months (median, 41 months). RESULTS: The PSA failure rate was 39%, 52.9%, and 42.8% at 12, 24, and 60 months of follow-up, respectively. Overall complication rates were low, with 8% of urinary incontinence and no cases of rectal injury; however, 96% of erectile dysfunction occurred. The cryoablation procedure failed in 12 patients (57.2%); 7 (58.3%) of these were local failures (positive prostate biopsies). CONCLUSION: Percutaneous cryoablation of the prostate is a safe minimally invasive treatment, but it has poor PSA-free survival outcomes in high-risk prostate cancer patients.

Bibliographic Details

Main Authors:	El Hayek,Omar Reda, Alfer Jr.,Wladimir, Reggio,Ernesto, Pompeo,Antonio Carlos L., Arap,Sami, Srougi,Miguel
Format:	Digital revista
Language:	English
Published:	Faculdade de Medicina / USP 2007
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322007000200003
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