Layered double hydroxides for controlled fluoride release

Abstract This study aims to develop a nano-sized fluoridated layered double hydroxide (LDH)-based release system via hydrothermal treatment for the controlled delivery of fluoride (F-) ions in the oral environment. The synthesis of conventional LDH-type (C-LDH) precursor nanomaterials was conducted using a co-precipitation method at constant pH, and the nanoparticulate-LDH (N-LDH) was synthesized by a hydrothermal procedure. Fluoride LDH (F-LDH) products were obtained through indirect synthesis using the precursor ion-exchange technique by varying the agitation time (2 and 24 h) and temperature (25 and 40 °C) to produce 12 material samples. The materials were characterized by energy dispersive x-ray, hexamethyldisilazane, digital radiography x-ray, Fourier-transform infrared, thermogravimetric analysis, and scanning electron microscopy. Additionally, the F-release kinetic profile was evaluated for 21 d in neutral and acid media with mathematical model analysis. Products with varying F-quantities were obtained, revealing specific release profiles. In general, there was a higher F-release in the acid medium, with emphasis on F-LDH-8. Fluoride-LDH and controlled fluoride delivery was successfully obtained, proving the potential of these nanomaterials as alternative anti-caries agents.

Bibliographic Details

Main Authors:	CARDOSO,Clarissiane Serafim, FREITAS,Johnnatan Duarte de, SANTOS,Naile Roberta Lima dos, ALMEIDA JÚNIOR,Alexandre, BASÍLIO JÚNIOR,Irinaldo Diniz, NASCIMENTO,Ticiano Gomes do, GRILLO,Luciano Aparecido Meireles, PORTO,Isabel Cristina Celerino de Moraes, MARINHO,José Luis Gomes, SANTOS,Grazielle Emanuella de Souza dos, MEILI,Lucas, SAMPAIO,Fábio Correia, DORNELAS,Camila Braga
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Pesquisa Odontológica - SBPqO 2021
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242021000100278
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