Risk of leukemia in first degree relatives of patients with nonsyndromic cleft lip and palate

The aim of this study was to determine the frequency of leukemia in parents of patients with nonsyndromic cleft lip and/or cleft palate (NSCL/P). This case-control study evaluated first-degree family members of 358 patients with NSCL/P and 1,432 subjects without craniofacial alterations or syndromes. Statistical analysis was carried out using Fisher’s test. From the 358 subjects with NSCL/P, 3 first-degree parents had history of leukemia, while 2 out of 1,432 subjects from the unaffected group had a family history of leukemia. The frequency of positive family history of leukemia was not significantly increased in first-degree relatives of patients with NSCL/P.

Bibliographic Details

Main Authors:	GONÇALVES,Eduardo, MARTELLI,Daniella Reis Barbosa, COLETTA,Ricardo Della, VIEIRA,Alexandre Rezende, CALDEIRA,Antônio Prates, MARTELLI JÚNIOR,Hercílio
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Pesquisa Odontológica - SBPqO 2014
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242014000100501
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