Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation

Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation

Our objective was to determine the levels of lactate dehydrogenase, IL-6, IL-8, and VEGF, as well as the total and differential cell counts, in the pleural fluid of lung transplant recipients, correlating those levels with the occurrence and severity of rejection. We analyzed pleural fluid samples collected from 18 patients at various time points (up to postoperative day 4). The levels of IL-6, IL-8, and VEGF tended to elevate in parallel with increases in the severity of rejection. Our results suggest that these levels are markers of acute graft rejection in lung transplant recipients.

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Bibliographic Details
Main Authors: Camargo,Priscila Cilene León Bueno de, Afonso Jr,José Eduardo, Samano,Marcos Naoyuki, Acencio,Milena Marques Pagliarelli, Antonangelo,Leila, Teixeira,Ricardo Henrique de Oliveira Braga
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Pneumologia e Tisiologia 2014
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132014000400425
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