Regulatory T cells isolated from endometriotic peritoneal fluid express a different number of Toll-like receptors

ABSTRACT Objective To analyze and compare the expression of Toll-like receptors by regulatory T cells present in the peritoneal fluid of patients with and without endometriosis. Methods Regulatory T cells were isolated from peritoneal fluid of women with and without endometriosis, collected during surgery, and mRNA was extracted for analysis of Toll-like receptors expression by reverse-transcriptase polymerase chain reaction. Results Patients with endometriosis presented regulatory T cells expressing a larger number and variety of Toll-like receptors when compared to regulatory T cells from patients in the Control Group. Toll-like receptor-1 and Toll-like receptor-2 in regulatory T cells were expressed in both groups. All other expressed Toll-like receptors types were only found in regulatory T cells from the Endometriosis Group. Conclusion Patients with endometriosis had peritoneal regulatory T cells expressing various Toll-like receptors types.

Bibliographic Details

Main Authors:	Hernandes,Camila, Gueuvoghlanian-Silva,Bárbara Yasmin, Monnaka,Vitor Ulisses, Ribeiro,Natalia Mazini, Pereira,Welbert de Oliveira, Podgaec,Sérgio
Format:	Digital revista
Language:	English
Published:	Instituto Israelita de Ensino e Pesquisa Albert Einstein 2020
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100247
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