Association between hypovitaminosis D and frequency of pulmonary exacerbations in children and adolescents with cystic fibrosis

Abstract Objective We evaluated the association between vitamin D levels and nutritional status, pulmonary function and pulmonary exacerbations in children and adolescents with cystic fibrosis. Methods 25-hydroxyvitamin D (25(OH)D) levels of 37 children and adolescents were retrospectively evaluated. Pulmonary function, body mass index, height for age, and pulmonary exacerbations episodes were associated with vitamin D levels divided into two groups: sufficient (≥30ng/mL) and hypovitaminosis (<30ng/mL). Results Hypovitaminosis D (25(OH)D <30ng/mL) was observed in 54% of subjects. The mean level of 25(OH)D was 30.53±12.14ng/mL. Pulmonary function and nutritional status were not associated with vitamin D levels. Pulmonary exacerbations over a 2-year period (p=0.007) and the period from measurement up to the end of the follow-up period (p=0.002) were significantly associated with vitamin D levels. Conclusion Hypovitaminosis D was associated with higher rates of pulmonary exacerbations in this sample of children and adolescents with cystic fibrosis. Hypovitaminosis D should be further studied as a marker of disease severity in cystic fibrosis. Further prospective and randomized studies are necessary to investigate causality of this association.

Bibliographic Details

Main Authors:	Ongaratto,Renata, Rosa,Katiana Murieli da, Eloi,Juliana Cristina, Epifanio,Matias, Marostica,Paulo, Pinto,Leonardo Araújo
Format:	Digital revista
Language:	English
Published:	Instituto Israelita de Ensino e Pesquisa Albert Einstein 2018
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082018000100213
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