Higher maternal age is associated with higher occurrence of cleft lip/palate in neonates under intensive care

Aim To assess the prevalence of cleft lip and/or cleft palate (CL/P) and associated variables in neonates admitted to neonatal intensive care units (ICU). Methods Medical charts for neonates born and admitted to the ICU between 2012 and 2018 were reviewed. Obstetric and neonatal variables were collected by a trained researcher. In the case group, all neonates with CL/P were included. The control group was formed by matching sex, prematurity and month of birth using random number generation. Neonates with congenital malformations were excluded from the control group. Adjusted logistic regression was used (p<0.05). Results The prevalence of CL/P was 0.43% (n=15). Five cases were excluded, as pairing was not possible. Twenty neonates were included in the control group. In the final multivariate model, CL/P was only associated with increased maternal age. For each year of increase in maternal age, neonates had a 35.2% higher chance of presenting CL/P (95% confidence interval: 1.021–1.792). Conclusions Higher maternal age was associated with higher occurrence of CL/P in neonates admitted to the ICU. No other neonatal or maternal independent variables were associated with CL/P. Due to missing data, interpretation of study results must be approached with caution.

Bibliographic Details

Main Authors:	Maurique,Luísa de Souza, Muniz,Francisco Wilker Mustafa Gomes, Silveira,Nathalia Preissler Vaz, Camassola,Melissa, Oliveira,Bibiana Mello de
Format:	Digital revista
Language:	English
Published:	Faculdade de Odontologia de Piracicaba - UNICAMP 2023
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-32252023000100307
Tags:	Add Tag No Tags, Be the first to tag this record!