RAGE receptor and its soluble isoforms in diabetes mellitus complications

Chronic hyperglycemia, which is present in all types of diabetes, increases the formation of advanced glycation end-products (AGEs). The interaction of AGEs with receptor of advanced glycation end-products (RAGE) initiates a cascade of pro-inflammatory and pro-coagulant processes that result in oxidative stress, stimulating the formation and accumulation of more AGE molecules. This cyclic process, denominated metabolic memory, may explain the persistency of diabetic vascular complications in patients with satisfactory glycemic control. The RAGE found in several cell membranes is also present in soluble isoforms (esRAGE and cRAGE), which are generated by alternative deoxyribonucleic acid splicing or by proteolytic cleavage. This review focuses on new research into these mediators as potential biomarkers for vascular complications in diabetes.

Bibliographic Details

Main Authors:	Oliveira,Mauren Isfer Anghebem, Souza,Emanuel Maltempi de, Pedrosa,Fábio de Oliveira, Réa,Rosângela Roginski, Alves,Alexessander da Silva Couto, Picheth,Geraldo, Rego,Fabiane Gomes de Moraes
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Patologia Clínica 2013
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000200004
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