Novel nonsense mutation in the katA gene of a catalase-negative Staphylococcus aureus strain
Abstract We report the first description of a rare catalase-negative strain of Staphylococcus aureus in Chile. This new variant was isolated from blood and synovial tissue samples of a pediatric patient. Sequencing analysis revealed that this catalase-negative strain is related to ST10 strain, which has earlier been described in relation to S. aureus carriers. Interestingly, sequence analysis of the catalase gene katA revealed presence of a novel nonsense mutation that causes premature translational truncation of the C-terminus of the enzyme leading to a loss of 222 amino acids. Our study suggests that loss of catalase activity in this rare catalase-negative Chilean strain is due to this novel nonsense mutation in the katA gene, which truncates the enzyme to just 283 amino acids.
Main Authors: | , , , , , , , , , , , |
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Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Microbiologia
2016
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Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000100177 |
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