Antibacterial activity of orsellinates

In order to obtain new compounds with antibacterial activity, the derivatives 2,4-dihydroxy-6-methylbenzoic acid (orsellinic acid) and 2,4-dihydroxy-6-methylbenzoates (orsellinates) were obtained through alcoholyses of lecanoric acid. All these substances were tested against Gram-positive and Gram-negative bacteria by a microdilution method. Staphylococcus aureus, Xanthomonas campestris var. vesicatoria and Ralstonia solanacearum were most sensitive to n-propyl 2,4-dihydroxy-6-methylbenzoate, n-pentyl 2,4-dihydroxy-6-methylbenzoate and n-hexyl 2,4-dihydroxy-6-methylbenzoate with MIC (Minimal Inhibitory Concentration) values ranging from 62.5 to 7.8 µg×mL¹. These results showed that homologation in carbon chain may lead to compounds with more pronunced activities.

Bibliographic Details

Main Authors:	Gomes,Alcir Teixeira, Smania Júnior,Artur, Seidel,Cintia, Smania,Elza de Fátima Albino, Honda,Neli Kika, Roese,Fernanda Mesquita, Muzzi,Rozanna Marques
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Microbiologia 2003
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822003000300002
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