Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility

The aim of this work was to study the effect of Halymenia floresia (Hf) on duodenum contractility, and on experimental protocols of gastric compliance (GC) in rats. Fraction Hf2s exhibited a concentration-dependent myocontractile effect (EC50 12.48 µg/ml), and an inhibitory effect after consecutive washing. The contractile response promoted by Hf2s in the duodenum strips was completely inhibited by verapamil, and the effects were prevented in the presence of Ca2+-free medium. The pretreatment with atropine prevented the Hf2s myocontractile effect. Hf2s was also capable to decrease the GC (from 3.8±0.06 to 3.4±0.13 ml, P<0.05), which did not return to basal levels after more 50 min of observation. These results indicated that the algal polysaccharide possessed in vitro and in vivo gastrointestinal effects.

Bibliographic Details

Main Authors:	Graça,José Ronaldo Vasconcelos, Bezerra,Mirna Marques, Lima,Vilma, Rodrigues,José Ariévilo Gurgel, Monteiro,Diego Levi Silveira, Quinderé,Ana Luíza Gomes, Amorim,Rodrigo César das Neves, Paula,Regina Célia Monteiro de, Benevides,Norma Maria Barros
Format:	Digital revista
Language:	English
Published:	Instituto de Tecnologia do Paraná - Tecpar 2011
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500008
Tags:	Add Tag No Tags, Be the first to tag this record!