Development and evaluation of a hydrophilic matrix as a buccoadhesive system containing diclofenac sodium
The aim of this work was to study the development and evaluation of a hydrolphilic matrix as a buccoadhesive system containing diclofenac sodium. Eleven formulations were prepared containing the following bioadhesive polymers: hydroxylpropylmethylcellulose, polycarbophil, guar gum and xanthan gum individually and in combination. All the formulations were evaluated for the swelling index, adhesive index, and the time of adhesive and drug release profile (%). The results showed that the formulations that presented the most swelling index were the F3 (PAA/GX) and F6 (GG/GX). The smaller index swelling was for F1 (PAA/CM) and F10 (HPCMC/CM). The F4 (PAA/HPMC) formulation presented the best adhesive index and F10 (HPMC/CM) the worst. F1 (PAA/CM) was the best matrix hydrophilic adhesive for controlled release. The hydroxylpropylmethylcellulose, guar and xanthan gum when used individually presented low adhesiveness.
| Main Authors: | , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Instituto de Tecnologia do Paraná - Tecpar
2011
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500006 |
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