Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats
Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas' disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when administered to rats treated for thirty days with benznidazole.
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Instituto de Tecnologia do Paraná - Tecpar
2008
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oai:scielo:S1516-891320080007000282009-02-20Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar ratsBarbosa,Vanessa Santos de ArrudaHolanda,Maria de Carvalho XavierSilva,Roseane Pereira daOliveira,Daniel Pereira deSilva Júnior,Maurício Ferreira daOliveira,Elias Herculano deSpyrides,Maria Helena ConstantinoMedeiros,Aldo Cunha Antiparasite Radiopharmaceutical Technetium-99m Benznidazole Biodistribution Trypanosoma cruzi Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas' disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when administered to rats treated for thirty days with benznidazole.info:eu-repo/semantics/openAccessInstituto de Tecnologia do Paraná - TecparBrazilian Archives of Biology and Technology v.51 n.spe 20082008-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700028en10.1590/S1516-89132008000700028 |
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Barbosa,Vanessa Santos de Arruda Holanda,Maria de Carvalho Xavier Silva,Roseane Pereira da Oliveira,Daniel Pereira de Silva Júnior,Maurício Ferreira da Oliveira,Elias Herculano de Spyrides,Maria Helena Constantino Medeiros,Aldo Cunha |
| spellingShingle |
Barbosa,Vanessa Santos de Arruda Holanda,Maria de Carvalho Xavier Silva,Roseane Pereira da Oliveira,Daniel Pereira de Silva Júnior,Maurício Ferreira da Oliveira,Elias Herculano de Spyrides,Maria Helena Constantino Medeiros,Aldo Cunha Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats |
| author_facet |
Barbosa,Vanessa Santos de Arruda Holanda,Maria de Carvalho Xavier Silva,Roseane Pereira da Oliveira,Daniel Pereira de Silva Júnior,Maurício Ferreira da Oliveira,Elias Herculano de Spyrides,Maria Helena Constantino Medeiros,Aldo Cunha |
| author_sort |
Barbosa,Vanessa Santos de Arruda |
| title |
Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats |
| title_short |
Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats |
| title_full |
Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats |
| title_fullStr |
Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats |
| title_full_unstemmed |
Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats |
| title_sort |
effect of tripanosomicide benznidazole (rochagan®) on the biodistribution of sodium pertechnetate (na99mtco4) in wistar rats |
| description |
Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas' disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when administered to rats treated for thirty days with benznidazole. |
| publisher |
Instituto de Tecnologia do Paraná - Tecpar |
| publishDate |
2008 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700028 |
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