Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats

Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas' disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when administered to rats treated for thirty days with benznidazole.

Bibliographic Details

Main Authors:	Barbosa,Vanessa Santos de Arruda, Holanda,Maria de Carvalho Xavier, Silva,Roseane Pereira da, Oliveira,Daniel Pereira de, Silva Júnior,Maurício Ferreira da, Oliveira,Elias Herculano de, Spyrides,Maria Helena Constantino, Medeiros,Aldo Cunha
Format:	Digital revista
Language:	English
Published:	Instituto de Tecnologia do Paraná - Tecpar 2008
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700028
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