Antimicrobial effectiveness of maleimides on fungal strains isolated from onychomycosis

Antimicrobial effectiveness of maleimides on fungal strains isolated from onychomycosis

This study aimed to analyze the effectiveness of maleimides as inhibitors on the growth of fungal strains isolated from onychomycosis by the solid medium diffusion procedure. The results showed a promising antifungical activity of the assayed maleimides with formation of fungal growth inhibition halos oscillating between diameter 10 and 23mm. MIC was 100µg/mL for 3,4-dichloro-N-phenyl-methyl-maleimide and 3,4-dichloro-N-phenyl-propil-maleimide and 200µg/mL for 3,4-dichloro-N-phenyl-maleimide, 3,4-dichloro-N-phenyl-ethyl-maleimide and 3,4-dichloro-N-phenyl-buthyl-maleimide.

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Bibliographic Details
Main Authors: Gayoso,Carla Wanderley, Lima,Edeltrudes de Oliveira, Souza,Evandro Leite de, Cechinel Filho,Valdir, Trajano,Vinícius Nogueira, Pereira,Fillipe de Oliveira, Lima,Igara Oliveira
Format: Digital revista
Language:English
Published: Instituto de Tecnologia do Paraná - Tecpar 2006
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000500016
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