Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton

Atherosclerosis is a coronary disease where deposition of lipids in the arteries leads to problems of blood circulation. The present work evaluates the action of the flavonoids morin, quercetin and nicotinic acid isolated in association on lipid metabolism in hyperlipidemic rats. Blood serum levels cholesterol, cholesterol-HDL, and triacylglycerids have been analysed following the intraperitoneal administration of the flavonoid compounds dissolved in propyleneglycol by in doses of 5mg/kg body weight. Quercetin presented the largest percentual reduction of cholesterol. The best results for cholesterol-HDL have been obtained with-nicotinic acid alone while morin-nicotinic acid combination showed the best triacylglycerols results. Results showed that flavonoids could be beneficious in the treatment of coronary diseases.

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Bibliographic Details
Main Authors: Ricardo,Kelly Fabiane Santos, Oliveira,Tânia Toledo de, Nagem,Tanus Jorge, Pinto,Aloisio da Silva, Oliveira,Maria Goreti Almeida, Soares,José Francisco
Format: Digital revista
Language:English
Published: Instituto de Tecnologia do Paraná - Tecpar 2001
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132001000300007
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