An integrated approach to identify bimodal genes associated with prognosis in câncer

Abstract Bimodal gene expression (where a gene expression distribution has two maxima) is associated with phenotypic diversity in different biological systems. A critical issue, thus, is the integration of expression and phenotype data to identify genuine associations. Here, we developed tools that allow both: i) the identification of genes with bimodal gene expression and ii) their association with prognosis in cancer patients from The Cancer Genome Atlas (TCGA). Bimodality was observed for 554 genes in expression data from 25 tumor types. Furthermore, 96 of these genes presented different prognosis when patients belonging to the two expression peaks were compared. The software to execute the method and the corresponding documentation are available at the Data access section.

Bibliographic Details

Main Authors:	Justino,Josivan Ribeiro, Reis,Clovis Ferreira dos, Fonseca,Andre Luis, Souza,Sandro Jose de, Stransky,Beatriz
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Genética 2021
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000400801
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