Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil

Methylenetetrahydrofolate reductase (MTHFR: EC 1.5.1.20) polymorphisms are associated to acute lymphoid leukemia in different populations. We used the polymerase chain reaction and the restriction fragment length polymorphism method (PCR-RFLP) to investigate MTHFR C677T and A1298C polymorphism frequencies in 67 patients with chronic myeloid leukemia (CML), 27 with acute myeloid leukemia FAB subtype M3 (AML-M3) and 100 apparently healthy controls. The MTHFR mutant allele frequencies were as follows: CML = 17.2% for C677T, 21.6% for A1298C; AML-M3 = 22.2% for C677T, 24.1% for A1298C; and controls = 20.5% for C677T, 21% for A1298C. Taken together, our results provide evidence that MTHFR polymorphisms have no influence on the development of CML or AML-M3.

Bibliographic Details

Main Authors:	Barbosa,Cynara Gomes, Souza,Claudio Lima, Moura Neto,José Pereira de, Arruda,Maria da Glória Bomfim, Barreto,José Henrique, Reis,Mitermayer Galvão, Goncalves,Marilda Souza
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Genética 2008
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000100005
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