Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats
Seeds of Crotalaria spectabilis, containing the pyrrolizidine alkaloid (PA) monocrotaline (MCT), were fed to a lactating dairy goat. Milk from this goat was fed to rats for 8 weeks to determine whether MCT or its toxic metabolites are transferred into the goats milk. Rats from the experimental group showed significantly higher (p<0.05) serum levels of ALT, AST, GGT and LDH and less weight gains (p<0.05) than control rats. The most significant lesions in rats consuming the experimental ration were mild to moderate interstitial pneumonia and a vacuolar degeneration and occasionally necrosis of periportal hepatocytes. The results of this study indicate that the PA and/or its metabolites are eliminated in milk.
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Digital revista |
| Language: | English |
| Published: |
Faculdade de Medicina Veterinária e Zootecnia / Universidade de São Paulo
1999
|
| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95961999000200008 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|