Short-interfering RNAs as antivirals against rabies
This study aimed to test in vitro a RNA-interference based antiviral approach for rabies with short-interfering RNAs (siRNAs) against rabies virus nucleoprotein mRNA. BHK-21 cells were infected with serial dilutions of PV rabies virus strain and transfected with a pool of three siRNAs. Direct immunofluorescence staining showed a 5-time decrease in virus titer when compared to a non-treated plate, showing a promising new approach to the development of antivirals for rabies treatment.
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Main Authors: | , , , , , , , |
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Format: | Digital revista |
Language: | English |
Published: |
Brazilian Society of Infectious Diseases
2007
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Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200011 |
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