Short-interfering RNAs as antivirals against rabies

Short-interfering RNAs as antivirals against rabies

This study aimed to test in vitro a RNA-interference based antiviral approach for rabies with short-interfering RNAs (siRNAs) against rabies virus nucleoprotein mRNA. BHK-21 cells were infected with serial dilutions of PV rabies virus strain and transfected with a pool of three siRNAs. Direct immunofluorescence staining showed a 5-time decrease in virus titer when compared to a non-treated plate, showing a promising new approach to the development of antivirals for rabies treatment.

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Bibliographic Details
Main Authors: Brandão,Paulo Eduardo, Castilho,Juliana Galera, Fahl,Willian, Carnieli Jr.,Pedro, Oliveira,Rafael de Novaes, Macedo,Carla Isabel, Carrieri,Maria Luiza, Kotait,Ivanete
Format: Digital revista
Language:English
Published: Brazilian Society of Infectious Diseases 2007
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200011
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200011

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