Plasma prevalence of anti-N-methyl-d-aspartate receptor IgG antibodies in early stages of psychosis

Abstract We investigated the feasibility of including plasma anti-NMDAR antibody screening in the assessment of first-episode psychosis patients in an early intervention programme in the Southern hemisphere. Anti-NMDAR IgG antibodies were assessed by ELISA in 166 patients (64.0% men), 166 matched population-based controls and 76 patients’ siblings (30.3% men). Fisher’s exact test and ANOVA were performed. Positive anti-NMDAR antibody patients were more often observed in bipolar disorder (10.0%) than schizophrenia (2.4%) or psychotic depression (3.1%), although no significant differences were observed. Our results are not conclusive regarding the inclusion of plasma anti-NMDAR IgG antibodies in differential diagnostic protocols for psychosis.

Bibliographic Details

Main Authors:	Loureiro,Camila Marcelino, Corsi-Zuelli,Fabiana, Fachim,Helene Aparecida, Shuhama,Rosana, Chagas,Natália Mota de Souza, Menezes,Paulo Rossi, Del-Ben,Cristina Marta, Louzada-Junior,Paulo
Format:	Digital revista
Language:	English
Published:	ABRASCO - Associação Brasileira de Saúde Coletiva 2021
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232021000301085
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