Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin: report of two cases
Gilbert's syndrome is a benign condition characterized by asymptomatic sporadic episodes of jaundice, due to a mild unconjugated hyperbilirubinemia caused by a deficiency in bilirubin glucoronidation. Under certain physiologic or pathologic events, bilirubin level rises but according to literature it does not reach out more than 3 mg/dl. We report 2 cases of Gilbert's syndrome, genetically tested, which presented with bilirubin levels above 6 mg/dl without any trigger or coexisting condition. In conclusion, bilirubin levels higher than 6 mg/dl in Gilbert syndrome are rare, hemolytic and other metabolism diseases must be ruled out, and genetic testing may be necessary in some cases.
Main Authors: | , , , , , |
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Format: | Digital revista |
Language: | English |
Published: |
Sociedad Española de Patología Digestiva
2016
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Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000400010 |
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