Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin: report of two cases

Gilbert's syndrome is a benign condition characterized by asymptomatic sporadic episodes of jaundice, due to a mild unconjugated hyperbilirubinemia caused by a deficiency in bilirubin glucoronidation. Under certain physiologic or pathologic events, bilirubin level rises but according to literature it does not reach out more than 3 mg/dl. We report 2 cases of Gilbert's syndrome, genetically tested, which presented with bilirubin levels above 6 mg/dl without any trigger or coexisting condition. In conclusion, bilirubin levels higher than 6 mg/dl in Gilbert syndrome are rare, hemolytic and other metabolism diseases must be ruled out, and genetic testing may be necessary in some cases.

Bibliographic Details

Main Authors:	Flores-Villalba,Eduardo, Rodriguez-Montalvo,Carlos, Arredondo-Saldaña,Gabriela, Bosques-Padilla,Francisco, Zertuche-Maldonado,Tania, Torre-Flores,Landy
Format:	Digital revista
Language:	English
Published:	Sociedad Española de Patología Digestiva 2016
Online Access:	http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000400010
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