Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin: report of two cases
Gilbert's syndrome is a benign condition characterized by asymptomatic sporadic episodes of jaundice, due to a mild unconjugated hyperbilirubinemia caused by a deficiency in bilirubin glucoronidation. Under certain physiologic or pathologic events, bilirubin level rises but according to literature it does not reach out more than 3 mg/dl. We report 2 cases of Gilbert's syndrome, genetically tested, which presented with bilirubin levels above 6 mg/dl without any trigger or coexisting condition. In conclusion, bilirubin levels higher than 6 mg/dl in Gilbert syndrome are rare, hemolytic and other metabolism diseases must be ruled out, and genetic testing may be necessary in some cases.
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Sociedad Española de Patología Digestiva
2016
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oai:scielo:S1130-010820160004000102016-06-17Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin: report of two casesFlores-Villalba,EduardoRodriguez-Montalvo,CarlosArredondo-Saldaña,GabrielaBosques-Padilla,FranciscoZertuche-Maldonado,TaniaTorre-Flores,Landy Gilbert's syndrome Jaundice Unconjugated hyperbilirubinemia Gilbert's syndrome is a benign condition characterized by asymptomatic sporadic episodes of jaundice, due to a mild unconjugated hyperbilirubinemia caused by a deficiency in bilirubin glucoronidation. Under certain physiologic or pathologic events, bilirubin level rises but according to literature it does not reach out more than 3 mg/dl. We report 2 cases of Gilbert's syndrome, genetically tested, which presented with bilirubin levels above 6 mg/dl without any trigger or coexisting condition. In conclusion, bilirubin levels higher than 6 mg/dl in Gilbert syndrome are rare, hemolytic and other metabolism diseases must be ruled out, and genetic testing may be necessary in some cases.Sociedad Española de Patología DigestivaRevista Española de Enfermedades Digestivas v.108 n.4 20162016-04-01journal articletext/htmlhttp://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000400010en |
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Flores-Villalba,Eduardo Rodriguez-Montalvo,Carlos Arredondo-Saldaña,Gabriela Bosques-Padilla,Francisco Zertuche-Maldonado,Tania Torre-Flores,Landy |
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Flores-Villalba,Eduardo Rodriguez-Montalvo,Carlos Arredondo-Saldaña,Gabriela Bosques-Padilla,Francisco Zertuche-Maldonado,Tania Torre-Flores,Landy Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin: report of two cases |
| author_facet |
Flores-Villalba,Eduardo Rodriguez-Montalvo,Carlos Arredondo-Saldaña,Gabriela Bosques-Padilla,Francisco Zertuche-Maldonado,Tania Torre-Flores,Landy |
| author_sort |
Flores-Villalba,Eduardo |
| title |
Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin: report of two cases |
| title_short |
Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin: report of two cases |
| title_full |
Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin: report of two cases |
| title_fullStr |
Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin: report of two cases |
| title_full_unstemmed |
Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin: report of two cases |
| title_sort |
unusual presentation of gilbert disease with high levels of unconjugated bilirubin: report of two cases |
| description |
Gilbert's syndrome is a benign condition characterized by asymptomatic sporadic episodes of jaundice, due to a mild unconjugated hyperbilirubinemia caused by a deficiency in bilirubin glucoronidation. Under certain physiologic or pathologic events, bilirubin level rises but according to literature it does not reach out more than 3 mg/dl. We report 2 cases of Gilbert's syndrome, genetically tested, which presented with bilirubin levels above 6 mg/dl without any trigger or coexisting condition. In conclusion, bilirubin levels higher than 6 mg/dl in Gilbert syndrome are rare, hemolytic and other metabolism diseases must be ruled out, and genetic testing may be necessary in some cases. |
| publisher |
Sociedad Española de Patología Digestiva |
| publishDate |
2016 |
| url |
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000400010 |
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