Multiple malignant primary neoplasms in patients with gastric neoplasms in the health district of León

Objectives: we analyzed the characteristics of patients with gastric tumors diagnosed with multiple malignant primary neoplasm (MMPN) in the Health District of León. Material and methods: using the information in the Tumor Registry at León Hospital patients selected were those with gastric neoplasms diagnosed between 1993 and 2002. A follow-up was performed until December 31, 2004, and the characteristics of patients diagnosed with a second neoplasm were analyzed. Results: MMPN prevalence was 1,96%; 56% of patients had a history of cancer in first-degree relatives. The most frequent second neoplasms were digestive (26%) and urologic (21%); 87% of patients were diagnosed with a second neoplasm within the first two years. No significative differences in survival were observed among patients with synchronous or metachronous MMPN. Conclusions: MMPN in patients with gastric neoplasms is a relevant problem. While external carcinogenic agents could act as promoters in the development of second neoplasms, these patients seem to have a genetic background favoring the development of MMPN. Secondary prevention is the best measure to avoid MMPN development.

Bibliographic Details

Main Authors:	Muela Molinero,A., Jorquera Plaza,F., Ribas Ariño,T., Malagón Rojo,R., Espinel Díez,V., Ballesteros del Río,B., Olcoz Goñi,J. L., Santos Calderón,J. A.
Format:	Digital revista
Language:	English
Published:	Sociedad Española de Patología Digestiva 2006
Online Access:	http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082006001200003
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