Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction
Abstract Depending on the age of onset, the excessive release of growth hormone (GH) − most commonly by a pituitary tumor − and subsequently of insulin-like growth factor 1 (IGF1) can cause acromegaly and gigantism. The purpose of this study was to describe the clinical manifestations and main known causes of GH overproduction. GH-releasing hormone and IGF1 can result in a series of physical traits and comorbidities due to hormonal imbalance and somatic overgrowth. To date, several syndromes and genetic mutations have been linked to the etiology of acromegaly.
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| Main Authors: | , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Centro Hospitalar do Porto
2023
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| Online Access: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200103 |
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